Jeremy Murray

10PUBLICATIONS
32CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsCharacterisation of biological macromoleculesMolecular targetsBiologically active moleculesBiomolecular modelling and design
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Publications (10)

|Oct 23, 2026
Lead Optimization of an Aminopyrazole Scaffold to EXEL-1855, a Highly Selective PLK4 Inhibitor with Potent Antitumor Efficacy.

|Dec 02, 2025
Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4.

Joon Won Jeong, Trevor Chang, Jeremy M Murray

|Jun 18, 2025
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.

Samantha A Green, Russell T Smith, Jessica M Grandner

|Jun 19, 2024
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.

Jun Liang, Michael J Lambrecht, Teresita L Arenzana

|Sep 22, 2023
Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).

Mingshuo Zeng, Jessica M Grandner, Marian C Bryan

|Oct 24, 2022
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.

Christopher McBride, Lynnie Trzoss, Davide Povero

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Frequent Collaborators

2 joint publications

Ziqiang Wang

2 joint publications

Joon Won Jeong

2 joint publications

Ryan L Gonciarz

2 joint publications

Justin M Salvant