John M Pascal

12PUBLICATIONS
47CO-AUTHORS
Cell development, proliferation and deathCancer diagnosisRadiation therapyStructural properties of condensed matterCheminformatics and quantitative structure-activity relationships
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Publications (12)

|Apr 29, 2026
PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly.

|Feb 16, 2026
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.

Aleksandr Sverzhinsky, Huijun Xue, Marie-France Langelier

|Dec 12, 2025
PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.

Mihaela Robu, Rashmi G Shah, Diana van den Heuvel

|Jan 13, 2025
Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.

Shang-Jung Cheng, Temitope Gafaar, Jijin R A Kuttiyatveetil

|Dec 06, 2024
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Nicholas C K Valerie, Kumar Sanjiv, Oliver Mortusewicz

|Nov 16, 2023
Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.

Léonie Frigon, John M Pascal

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Frequent Collaborators

4 joint publications

Marie-France Langelier

3 joint publications

Aleksandr Sverzhinsky

2 joint publications

Léonie Frigon

2 joint publications

Ramya Billur