Alfred H Schinkel

15PUBLICATIONS
15CO-AUTHORS
Molecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Health and ecological risk assessmentPharmacogenomicsPredictive and prognostic markers
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Publications (15)

|Sep 23, 2024
Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1c.

Jamie Rijmers, Rolf W Sparidans, Manon Acda

|Feb 29, 2024
Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice.

Nancy H C Loos, Margarida L Ferreira Martins, Jamie Rijmers

|Mar 28, 2023
Enhancement of the Oral Availability of Cabazitaxel Using the Cytochrome P450 3A (CYP3A) Inhibitor Ritonavir in Mice.

Nancy H C Loos, Margarida L F Martins, Daniëlle de Jong

|Sep 23, 2022
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure.

Jing Wang, M Merve Susam, Changpei Gan

|Sep 09, 2022
The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?

Nancy H C Loos, Jos H Beijnen, Alfred H Schinkel

|Jul 27, 2022
Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.

David Damoiseaux, Wenlong Li, Alejandra Martínez-Chávez

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Frequent Collaborators

5 joint publications

Jos H Beijnen

4 joint publications

Nancy H C Loos

4 joint publications

Margarida L Ferreira Martins

3 joint publications

Rolf W Sparidans