Tom de Bruyn

6PUBLICATIONS
25CO-AUTHORS
GeodynamicsBiomolecular modelling and designPharmacogenomicsMolecular targetsGlycoconjugates
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Publications (6)

|Jun 04, 2024
Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects.

Smita Kshirsagar, Ya-Chi Chen, Jiajie Yu

|May 15, 2024
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.

Marie-Gabrielle Braun, Avi Ashkenazi, Ramsay E Beveridge

|Nov 29, 2023
Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.

Vikram Malhi, Priya Agarwal, Mary R Gates

|May 10, 2023
Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds.

Jialin Mao, Fang Ma, Jesse Yu

|Apr 27, 2023
Physiologically-based pharmacokinetic/pharmacodynamic modeling to predict tumor growth inhibition and the efficacious dose of selective estrogen receptor degraders in humans.

Anjani Ganti, Sijia Yu, Danielle Sharpnack

|Aug 07, 2019
Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2.

Paul Oranje, Robin Gouka, Lindsey Burggraaff

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Frequent Collaborators

2 joint publications

Jiajie Yu

1 joint publications

Paul Oranje

1 joint publications

Lindsey Burggraaff

1 joint publications

Clément Chalet