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Darrin D Stuart

4PUBLICATIONS

34CO-AUTHORS

Molecular targets

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Publications (4)

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|Jun 04, 2025

STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models.

Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram

|Sep 15, 2023

Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.

Darrin D Stuart, Angel Guzman-Perez, Natasja Brooijmans

|Aug 25, 2023

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.

Leonard Buckbinder, David J St Jean, Trang Tieu

|Mar 12, 2021

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.

Matthew S Crowe, Tatiana Zavorotinskaya, Charles F Voliva

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Frequent Collaborators

3 joint publications

Erica L Jackson

3 joint publications

Angel Guzman-Perez

3 joint publications

Gregory V Kryukov

3 joint publications

Natasja Brooijmans

2 joint publications

Brendon Ladd

2 joint publications

Brendan J Hilbert

2 joint publications

Weixue Wang

2 joint publications

Michael R Huff

1 joint publications

Petr Kuzmic

1 joint publications

Matthew D Shirley

Frequent Collaborators

3 joint publications

Erica L Jackson

3 joint publications

Angel Guzman-Perez

3 joint publications

Gregory V Kryukov

3 joint publications

Natasja Brooijmans

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