Darrin D Stuart
4PUBLICATIONS
34CO-AUTHORS
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Publications (4)
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|Jun 04, 2025
STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models.Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram
|Sep 15, 2023
Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.Darrin D Stuart, Angel Guzman-Perez, Natasja Brooijmans
|Aug 25, 2023
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.Leonard Buckbinder, David J St Jean, Trang Tieu
|Mar 12, 2021
RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.Matthew S Crowe, Tatiana Zavorotinskaya, Charles F Voliva
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Frequent Collaborators
3 joint publications
Erica L Jackson
3 joint publications
Angel Guzman-Perez
3 joint publications
Gregory V Kryukov
3 joint publications
Natasja Brooijmans
2 joint publications
Brendon Ladd
2 joint publications
Brendan J Hilbert
2 joint publications
Weixue Wang
2 joint publications
Michael R Huff
1 joint publications
Petr Kuzmic
1 joint publications
Matthew D Shirley
