Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Isaac Dean

9PUBLICATIONS
70CO-AUTHORS
Molecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Medical mycologyMechanobiologyTumour immunology
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (9)

Sort by Publication Date:
|Mar 03, 2026
Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling.

Victoria Roulstone, Joan Kyula, Elizabeth Appleton

|Jul 15, 2025
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion.

Victoria Roulstone, Joan Kyula-Currie, James Wright

|Jun 16, 2025
In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade.

Colin Y C Lee, Isaac Dean, Nathan Richoz

|May 24, 2025
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion.

Victoria Roulstone, Joan Kyula-Currie, James Wright

|Oct 11, 2024
Type-H endothelial cell protein Clec14a orchestrates osteoblast activity during trabecular bone formation and patterning.

Georgiana Neag, Jonathan Lewis, Jason D Turner

|Jan 24, 2024
Tumour-retained activated CCR7<sup>+</sup> dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity.

Colin Y C Lee, Bethany C Kennedy, Nathan Richoz

Pageof 2

Frequent Collaborators

5 joint publications

David R Withers

4 joint publications

Scott A Hammond

4 joint publications

Bethany Kennedy

4 joint publications

Menna R Clatworthy

4 joint publications

Zhi Li

3 joint publications

Emmanuel Christian Patin

3 joint publications

Charleen Ml Chan Wah Hak

3 joint publications

Colin Yc Lee

3 joint publications

Victoria Roulstone

3 joint publications

Zewen K Tuong

Frequent Collaborators

5 joint publications

David R Withers

4 joint publications

Scott A Hammond

4 joint publications

Bethany Kennedy

4 joint publications

Menna R Clatworthy

Top Related Videos

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on : Jul 07, 2023

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on : Apr 26, 2024

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1<sup>+</sup> Tim-3<sup>+</sup> CD8<sup>+</sup> T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1<sup>+</sup> Tim-3<sup>+</sup> CD8<sup>+</sup> T Cells

Published on : Feb 08, 2018

14.8K
See more related videos

Top Related Videos

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on : Jul 07, 2023

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on : Apr 26, 2024

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1<sup>+</sup> Tim-3<sup>+</sup> CD8<sup>+</sup> T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1<sup>+</sup> Tim-3<sup>+</sup> CD8<sup>+</sup> T Cells

Published on : Feb 08, 2018

14.8K
See more related videos