James A Nieman

7PUBLICATIONS
26CO-AUTHORS
Biologically active moleculesCharacterisation of biological macromoleculesCheminformatics and quantitative structure-activity relationshipsMedical virologyProteins and peptides
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Publications (7)

|Dec 10, 2024
Discovery of Novel Pyrido[2,3-b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition.

Bing Bai, Appan Srinivas Kandadai, Mostofa Hena

|Dec 25, 2023
The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

Elena Arutyunova, Alexandr Belovodskiy, Pu Chen

|Jul 31, 2023
Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir.

Tayla J Van Oers, Alexia Piercey, Alexandr Belovodskiy

|May 01, 2023
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.

Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu

|Nov 15, 2021
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

Bing Bai, Elena Arutyunova, Muhammad Bashir Khan

|Jul 09, 2021
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.

Bing Bai, Alexandr Belovodskiy, Mostofa Hena

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Frequent Collaborators

5 joint publications

John C Vederas

5 joint publications

M Joanne Lemieux

3 joint publications

Tess Lamer

2 joint publications

Zoe Turner