Hiroaki Machiyama

6PUBLICATIONS
21CO-AUTHORS
Haematological tumoursMolecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Molecular medicine
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Publications (6)

|Feb 19, 2026
Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice.

Chihiro Ogawa, Kazuki Okuyama, Satoshi Kojo

|Jan 08, 2026
PD-1 suppresses CAR signaling by forming the inhibitory signalosome colocalizing to CAR microclusters.

Yosuke Yoshida, Hiroaki Machiyama, Ei Wakamatsu

|Oct 30, 2025
CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters.

Tetsushi Nishikawa, Arata Takeuchi, Hiroaki Machiyama

|Jun 06, 2023
Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters.

Wataru Nishi, Ei Wakamatsu, Hiroaki Machiyama

|May 15, 2021
PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment.

Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama

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