Yasunori Aoki

13PUBLICATIONS
15CO-AUTHORS
PharmacogenomicsPharmaceutical delivery technologiesEpidemiological modellingGastroenterology and hepatologyMedical genetics (excl. cancer genetics)
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Publications (13)

|Dec 09, 2025
Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics.

Yuki Iwaki, Wooin Lee, Yasunori Aoki

|Feb 07, 2025
Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss-Newton Method.

Takashi Yoshikado, Yasunori Aoki, Ryo Nakamura

|Nov 27, 2024
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharmacokinetic parameters?

Toshiaki Tsuchitani, Motohiro Kato, Atsuko Tomaru

|Oct 22, 2024
Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method.

Ryo Nakamura, Takashi Yoshikado, Yasunori Aoki

|May 15, 2024
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model.

Toshiaki Tsuchitani, Atsuko Tomaru, Yasunori Aoki

|Oct 19, 2023
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models.

Yasunori Aoki, Yuichi Sugiyama

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Frequent Collaborators

2 joint publications

Rebecca E Chandler

2 joint publications

Koji Chiba

2 joint publications

Yuichi Sugiyama

2 joint publications

Toshiaki Tsuchitani