Denis Bucher

5PUBLICATIONS
12CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsLasers and quantum electronicsCatalysis and mechanisms of reactionsBiomolecular modelling and design
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Publications (5)

|Jul 25, 2025
Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor.

Hans Kelgtermans, Maxim De Wachter, Stijn Heyndrickx

|Feb 06, 2023
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.

Mathieu Botte, Sophie Huber, Denis Bucher

|Sep 28, 2021
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.

Oscar Mammoliti, Koen Jansen, Sandy El Bkassiny

|Feb 09, 2019
Mechanistic Implications of Reductive Co-C Bond Cleavage in B<sub>12</sub>-Dependent Methylmalonyl CoA Mutase.

Neeraj Kumar, Denis Bucher, Pawel M Kozlowski

|Mar 01, 2018
Shedding Light on Important Waters for Drug Design: Simulations versus Grid-Based Methods.

Denis Bucher, Pieter Stouten, Nicolas Triballeau

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Frequent Collaborators

1 joint publications

Neeraj Kumar

1 joint publications

Pawel M Kozlowski

1 joint publications

Oscar Mammoliti

1 joint publications

Mohamed Chami