John O'Shea

19PUBLICATIONS
132CO-AUTHORS
Innate immunityHaematological tumoursAutoimmunityApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Genome structure and regulation
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Publications (19)

|Jun 18, 2026
Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.

|Feb 20, 2026
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.

Dominic P Golec, Pedro H Gazzinelli-Guimaraes, Daniel Chauss

|May 30, 2025
An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection.

Rachael L Philips, Yi-Chu Liao, Colleen M Lau

|Nov 20, 2024
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression.

Hiroyuki Nagashima, Justin Shayne, Kan Jiang

|Aug 09, 2024
3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network.

Pawel Trzaskoma, SeolKyoung Jung, Aleksandra Pękowska

|Jan 19, 2024
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation.

Tamara T Haque, Katherine A Weissler, Zoe Schmiechen

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Frequent Collaborators

5 joint publications

Yuka Kanno

5 joint publications

Alejandro Villarino

4 joint publications

Pamela L Schwartzberg

3 joint publications

Chen Yao