Janita Oosterhoff

6PUBLICATIONS
19CO-AUTHORS
AutoimmunityFoetal development and medicineInnate immunityApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
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Publications (6)

|Sep 26, 2026
A functionally distinct HPA-1a-specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa.

|Apr 14, 2026
Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity.

Wendy Stam, Jeremy D Broekhuis, Femke W T van der Meer

|Feb 11, 2026
Structural basis of HPA-1a alloimmunization in FNAIT and allosteric regulation of integrin conformation.

Heng Zhang, Cathy Paddock, Janita Oosterhoff

|Aug 11, 2025
HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins.

Janita J Oosterhoff, Wendy Stam, Suze R van Brummelen

|Feb 24, 2024
Generation of human antibodies targeting human platelet antigen (HPA)-1a.

Janita J Oosterhoff, Federica Linty, Remco Visser

|Jul 25, 2022
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.

Simone C Oostindie, Derek A Rinaldi, Gijs G Zom

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Frequent Collaborators

4 joint publications

Gestur Vidarsson

2 joint publications

Peter J Newman

2 joint publications

Debra Newman

2 joint publications

Jieqing Zhu