Mark Paetzel

5PUBLICATIONS
26CO-AUTHORS
Medical virologyCheminformatics and quantitative structure-activity relationshipsBacteriologyPredictive and prognostic markersCancer genetics
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Publications (5)

|Jun 03, 2025
Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.

Natalie M Deschenes, Jimena Pérez-Vargas, Zoe Zhong

|Aug 09, 2023
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.

Jimena Pérez-Vargas, Liam J Worrall, Andrea D Olmstead

|Jan 04, 2023
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.

J Andrew N Alexander, Liam J Worrall, Jinhong Hu

|Sep 03, 2022
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.

Jaeyong Lee, Calem Kenward, Liam J Worrall

|Nov 19, 2020
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.

Jaeyong Lee, Liam J Worrall, Marija Vuckovic

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Frequent Collaborators

4 joint publications

Natalie C J Strynadka

3 joint publications

Anh-Tien Ton

3 joint publications

Artem Cherkasov

2 joint publications

Jimena Pérez-Vargas