Michael A Letavic
4PUBLICATIONS
6CO-AUTHORS
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Publications (4)
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|Feb 09, 2023
Discovery of a Series of Substituted 1<i>H</i>-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.Christine F Gelin, Brice Stenne, Heather Coate
|Aug 14, 2020
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-<i>b</i>]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.Christa C Chrovian, Akinola Soyode-Johnson, Brice Stenne
|Dec 07, 2017
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.Christa C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson
|May 12, 2017
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.Michael A Letavic, Brad M Savall, Brett D Allison
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