Caroline Rynn

6PUBLICATIONS
20CO-AUTHORS
Human biophysicsBiologically active moleculesToxicology (incl. clinical toxicology)Molecular targetsCheminformatics and quantitative structure-activity relationships
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Publications (6)

|Mar 28, 2026
PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.

Farzaneh Salem, Ali Tabatabaeian Nimavardi, Abhishek Srivastava

|Feb 16, 2025
Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders.

Giulia Apprato, Giulia Caron, Gauri Deshmukh

|Jun 27, 2024
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders.

Caroline Rynn, Heide Marika Duevel

|Aug 25, 2022
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist.

Caroline Rynn, Kenichi Umehara, Tianyi Jiang

|Mar 26, 2022
Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers.

Katja Heinig, Filippo Sladojevich, Jeannine Petrig Schaffland

|Nov 16, 2021
Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor.

Jürgen Wichmann, Caroline Rynn, Thomas Friess

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Frequent Collaborators

2 joint publications

Heide Marika Duevel

1 joint publications

Martin Kornacker

1 joint publications

Jasmin Emmenegger

1 joint publications

Dominik Rüttinger