J Brad Shotwell

6PUBLICATIONS
40CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsMolecular targetsBiologically active moleculesGene and molecular therapyBiomolecular modelling and design
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Publications (6)

|May 25, 2026
Discovery of Potent and Orally Bioavailable Novel Cluster of Differentiation 38 (CD38) Small Molecule Inhibitors.

|Sep 18, 2025
Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.

Melat T Gebru, Timothy E Hoffman, Aaron Boudreau

|Apr 04, 2024
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.

Ashley L Ramos, Eric R Goedken, Kristine E Frank

|Feb 21, 2022
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.

Sven Malchow, Alla Korepanova, Sanjay C Panchal

|Feb 15, 2019
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.

Pek Y Chong, J Brad Shotwell, John Miller

|Jul 14, 2018
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner

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Frequent Collaborators

1 joint publications

Melat T Gebru

1 joint publications

Timothy E Hoffman

1 joint publications

Aaron Boudreau

1 joint publications

Ngoc Vu