Alfred L Goldberg

8PUBLICATIONS
11CO-AUTHORS
Cancer diagnosisPredictive and prognostic markersApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Cancer therapy (excl. chemotherapy and radiation therapy)Medical infection agents (incl. prions)
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (8)

|Jun 15, 2022
26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase.

Donghoon Lee, Alfred L Goldberg

|Jun 02, 2021
Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation.

Alfred L Goldberg, Hyoung Tae Kim, Donghoon Lee

|Aug 21, 2020
Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis.

Zhe Sha, Alfred L Goldberg

|Jun 10, 2020
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases.

Jordan J S VerPlank, Sylwia D Tyrkalska, Angeleen Fleming

|Mar 04, 2020
An allosteric switch regulates <i>Mycobacterium tuberculosis</i> ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.

Siavash Vahidi, Zev A Ripstein, Jordan B Juravsky

|Feb 20, 2020
Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation.

Galen A Collins, Alfred L Goldberg

Pageof 2

Frequent Collaborators

1 joint publications

Helena M Schnell

1 joint publications

Kerstin Ruoff

1 joint publications

Galen A Collins

1 joint publications

Siavash Vahidi