Brian A Lanman

7PUBLICATIONS
32CO-AUTHORS
Molecular targetsCharacterisation of biological macromoleculesMedical infection agents (incl. prions)
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Publications (7)

|Aug 13, 2026
Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor.

|Jul 14, 2026
Expanding Addressable KRAS Mutations through the Structure- and Property-Based Design of Dual-State (GDP/GTP), Reversible Pan-KRAS Inhibitors.

|Aug 21, 2025
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation.

Dhanusha A Nalawansha, Georgios Mazis, Gitte Husemoen

|Mar 27, 2025
Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers.

Liping H Pettus, Matthew Bourbeau, Nuria A Tamayo

|Feb 11, 2025
Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening.

David Huang, Francesco Manoni, Zhen Sun

|Sep 30, 2022
Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.

Brian A Lanman, Andrew T Parsons, Stephan G Zech

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Frequent Collaborators

3 joint publications

Nuria A Tamayo

3 joint publications

Upendra P Dahal

3 joint publications

Anne Y Saiki

2 joint publications

Prashant Agarwal