Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Francesca Deflorian

4PUBLICATIONS

13CO-AUTHORS

Biomolecular modelling and designCheminformatics and quantitative structure-activity relationships

Featured researcher

Get your video featured.

Publish with JoVE

Featured researcher

Get your video featured.

Publish with JoVE

Publications (4)

Sort by Publication Date:

|Jun 20, 2020

Structure-Based Drug Discovery of <i>N</i>-((<i>R</i>)-3-(7-Methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(((<i>S</i>)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-<i>d</i>][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.

Sarah J Bucknell, Mark A Ator, Alastair J H Brown

|Jun 17, 2020

X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A<sub>2A</sub> Adenosine Receptor Antagonists.

Willem Jespers, Grégory Verdon, Jhonny Azuaje

|Jun 17, 2020

Accurate Prediction of GPCR Ligand Binding Affinity with Free Energy Perturbation.

Francesca Deflorian, Laura Perez-Benito, Eelke B Lenselink

|Jan 09, 2018

Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A<sub>2A</sub> ligand binding kinetics.

Giuseppe Deganutti, Andrei Zhukov, Francesca Deflorian

Pageof 1

Frequent Collaborators

3 joint publications

Miles Congreve

2 joint publications

Chris de Graaf

1 joint publications

Laura Perez-Benito

1 joint publications

Eelke B Lenselink

1 joint publications

Herman W T van Vlijmen

1 joint publications

Gary Tresadern

1 joint publications

Willem Jespers

1 joint publications

Jhonny Azuaje

1 joint publications

Xerardo García-Mera

1 joint publications

Johan Åqvist

Frequent Collaborators

3 joint publications

Miles Congreve

2 joint publications

Chris de Graaf

1 joint publications

Laura Perez-Benito

1 joint publications

Eelke B Lenselink

Top Related Videos

<em>Ex Vivo</em> Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

<em>Ex Vivo</em> Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on : May 16, 2022

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Published on : Sep 20, 2016

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on : Mar 10, 2020

See more related videos

Top Related Videos

<em>Ex Vivo</em> Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

<em>Ex Vivo</em> Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on : May 16, 2022

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Published on : Sep 20, 2016

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on : Mar 10, 2020

See more related videos