Edgar Specker

6PUBLICATIONS
19CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsComputational physiologyCrystallographyComputational chemistryProteins and peptides
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (6)

|Jun 19, 2025
Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis.

Radoslaw Wesolowski, Anja Schütz, Michael Lisurek

|May 10, 2024
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats.

Radoslaw Wesolowski, Dirk Pleimes, Edgar Specker

|Oct 31, 2023
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.

Edgar Specker, Radoslaw Wesolowski, Anja Schütz

|Oct 11, 2023
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.

Murat Kücükdisli, Hassen Bel-Abed, Davide Cirillo

|Sep 30, 2022
Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands.

María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri

|Aug 03, 2022
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.

Edgar Specker, Susann Matthes, Radoslaw Wesolowski

Pageof 1

Frequent Collaborators

5 joint publications

Marc Nazaré

2 joint publications

Natalia Alenina

2 joint publications

Michael Bader

2 joint publications

Radoslaw Wesolowski