John Wr Schwabe

17PUBLICATIONS
111CO-AUTHORS
Medical molecular engineering of nucleic acids and proteinsCheminformatics and quantitative structure-activity relationshipsGenome structure and regulationChemical thermodynamics and energeticsEpigenetics (incl. genome methylation and epigenomics)
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Publications (17)

|Nov 25, 2025
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome.

Louise Fairall, Kristupas Sirvydis, Robert E Turnbull

|Sep 25, 2025
The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes.

Wiktoria A Pytel, Urvashi Patel, Joshua P Smalley

|Sep 18, 2025
Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation.

Ahmad Alshehri, India-May Baker, David M English

|Apr 25, 2025
Proline Amide Catalyzes Formation of Toxic Crotonaldehyde from Acetaldehyde Under Physiologically Relevant Conditions.

Liam A Thomas, Vicki L Emms, Dipti Vashi

|Oct 07, 2024
A circular engineered sortase for interrogating histone H3 in chromatin.

Samuel D Whedon, Kwangwoon Lee, Zhipeng A Wang

|Sep 25, 2024
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.

Sam M Lockhart, Milan Muso, Ilona Zvetkova

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Frequent Collaborators

6 joint publications

Louise Fairall

4 joint publications

Christopher J Millard

3 joint publications

Philip A Cole

3 joint publications

Beatriz Romartínez-Alonso