Yoshikazu Nishimura

6PUBLICATIONS
5CO-AUTHORS
Biomolecular modelling and designBiologically active moleculesProteins and peptidesToxicology (incl. clinical toxicology)
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Publications (6)

|Oct 23, 2026
Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides.

|Jan 26, 2024
Synthesis and Biological Evaluations of Novel Human Parathyroid Hormone 1 Receptor (hPTHR1) Agonists Bearing Bicyclic Aromatic Moiety.

Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki

|Oct 24, 2023
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara

|Jul 18, 2023
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo

|Feb 06, 2020
Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist.

Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki

|Jun 23, 2018
Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism.

Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki

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Frequent Collaborators

3 joint publications

Mikimasa Tanada

3 joint publications

Kenichi Nomura

2 joint publications

Toshiya Ito

1 joint publications

Ryusuke Takano