Kohnosuke Kinoshita

5PUBLICATIONS
2CO-AUTHORS
Pharmaceutical delivery technologiesPharmacogenomicsBiomolecular modelling and design
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Publications (5)

|Feb 08, 2023
Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression.

Shoko Inatani, Motoki Ochi, Kohnosuke Kinoshita

|Mar 17, 2022
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist.

Motoki Ochi, Kohnosuke Kinoshita, Jun-Ichi Yamaguchi

|Sep 17, 2021
Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents.

Mai Watanabe, Brian Marcy, Ayano Hiroki

|May 01, 2020
Safety and pharmacokinetic profiles of MGS0274 besylate (TS-134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects.

Mai Watanabe, Brian Marcy, Kohnosuke Kinoshita

|Sep 17, 2019
Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia.

Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata

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Frequent Collaborators

2 joint publications

Mai Watanabe

1 joint publications

Shoko Inatani