Alexandra Castilho

5PUBLICATIONS
12CO-AUTHORS
Plant pathologyBiologically active moleculesTumour immunologyGene and molecular therapyAgricultural molecular engineering of nucleic acids and proteins
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Publications (5)

|Mar 22, 2025
An engineered PD1-Fc fusion produced in N. benthamiana plants efficiently blocks PD1/PDL1 interaction.

Shiva Izadi, Rafaela Abrantes, Simon Gumpelmair

|Dec 05, 2023
Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding.

Shiva Izadi, Simon Gumpelmair, Pedro Coelho

|Oct 03, 2023
The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif.

Katharina Aigner-Radakovics, Annika De Sousa Linhares, Benjamin Salzer

|Nov 30, 2021
Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo.

Shiva Izadi, Mokhtar Jalali Javaran, Sajad Rashidi Monfared

|Dec 15, 2019
BGAL1 depletion boosts the level of β-galactosylation of N- and O-glycans in N. benthamiana.

Ricarda Kriechbaum, Esmaiel Ziaee, Clemens Grünwald-Gruber

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