Michael J Eck

23PUBLICATIONS
159CO-AUTHORS
Molecular targetsInstruments and techniquesCancer therapy (excl. chemotherapy and radiation therapy)Innate immunityBiomolecular modelling and design
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Publications (23)

|Sep 09, 2026
O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis.

|Aug 27, 2026
Towards better outcomes for epidermal growth factor receptor L858R+ lung cancer patients: mutant-selective allosteric inhibitors and the potential for double-drugging.

|May 25, 2026
Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation.

|Feb 03, 2026
Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2-Driven Tumors.

Francesco Facchinetti, Antoine Hollebecque, Rémy Barbé

|Dec 25, 2025
RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor.

Sayan Chakraborty, Jie Jiang, Javier Vinals Camallonga

|Sep 01, 2025
Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation.

Dong Man Jang, Kayla Boxer, Byung Hak Ha

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Frequent Collaborators

7 joint publications

David Heppner

7 joint publications

Tyler S Beyett

6 joint publications

Hyesung Jeon

5 joint publications

Anna Schmoker