Georgette M Castanedo

6PUBLICATIONS
16CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsMedical devicesApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)Organometallic chemistry
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Publications (6)

|Jun 17, 2026
Optimization and In Vivo Characterization of a Series of Cbl‑b Inactive-State Inhibitors.

|Jun 17, 2026
Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy.

|Mar 12, 2024
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.

Ruth Dorel, Dawei Sun, Nicholas Carruthers

|Feb 20, 2018
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

James J Crawford, Adam R Johnson, Dinah L Misner

|Jul 21, 2017
Introduction of Trifluoroethylamine as Amide Isostere by C-H Functionalization of Heteroarenes.

Marie-Gabrielle Braun, Georgette Castanedo, Ling Qin

|Dec 23, 2016
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).

Georgette M Castanedo, Nicole Blaquiere, Maureen Beresini

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Frequent Collaborators

3 joint publications

Peter Man-Un Ung

2 joint publications

Peter L Hsu

2 joint publications

Xiaojing Wang

2 joint publications

Robin Larouche-Gauthier