Laurent Leclercq
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3CO-AUTHORS
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Publications (2)
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|May 06, 2025
Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi.Megan Ford, Paul J Thomson, Adam Lister
|Dec 11, 2024
CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.Laurent Leclercq, Ronald de Vries, Valérie Koppen
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