Kevin M Cottrell

5PUBLICATIONS

18CO-AUTHORS

Molecular targetsGene and molecular therapyMedical infection agents (incl. prions)

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Publications (5)

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|May 18, 2026

The Discovery of TNG456: A Highly Potent, Selective, Brain-Penetrant MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers.

|Jun 24, 2025

MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models.

Xiaochun Zhang, Dana C Borcherding, Minjie Zhang

|Mar 04, 2025

Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.

Kevin M Cottrell, Kimberly J Briggs, Alice Tsai

|Feb 07, 2025

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.

Kevin M Cottrell, Douglas A Whittington, Kimberly J Briggs

|Apr 10, 2024

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.

Kevin M Cottrell, Kimberly J Briggs, Douglas A Whittington

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Frequent Collaborators

5 joint publications

John P Maxwell

4 joint publications

Douglas A Whittington

Xiaochun Zhang

Dana C Borcherding

Minjie Zhang

Yang Lyu

Guangfeng Wang

Kevin He

Gorkem Oztosun

Ishita Sachdeva

Frequent Collaborators

5 joint publications

John P Maxwell

4 joint publications

Douglas A Whittington

1 joint publications

Xiaochun Zhang

1 joint publications

Dana C Borcherding