Related Experiment Video

Updated: Aug 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

[Interferon gamma as a regulator of immune cell function]

A Szuster-Ciesielska1, M Kandefer-Szerszeń

  • 1Zakład Wirusologii i Immunologii, Instytutu Mikrobiologii i Biotechnologii, Uniwersytetu Marii Curie-Skłodowskiej w Lublinie.

Postepy Higieny I Medycyny Doswiadczalnej
|June 3, 1999
PubMed

Insights

This review covers how specific cells produce interferon-gamma (IFN-gamma), its gene structure, and signaling pathways. It also discusses IFN-gamma

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Context:

  • Interferon-gamma (IFN-gamma) is a critical cytokine in immune responses.
  • Understanding IFN-gamma's role requires knowledge of its production, gene, and signaling.
  • Immune cell function is modulated by IFN-gamma and its interactions.

Purpose:

  • To review the literature on lymphocyte subsets producing IFN-gamma.
  • To describe the structure of the IFN-gamma gene.
  • To elucidate the IFN-gamma signal transduction pathway and its cellular effects.
  • To discuss IFN-gamma's interaction with other cytokines in immune regulation.

Summary:

  • Identifies lymphocyte subsets that produce IFN-gamma upon specific induction.
  • Details the genetic structure of IFN-gamma.
  • Explains the signal transduction pathway initiated by IFN-gamma, leading to cellular biochemical changes.
  • Illustrates how IFN-gamma influences immunocompetent cells, including mononuclear phagocytes, T lymphocytes, and B lymphocytes.
  • Examines the interplay between IFN-gamma and other cytokines in modulating the overall immune response.

Impact:

  • Provides a comprehensive overview of IFN-gamma biology for researchers.
  • Facilitates understanding of immune regulation mechanisms.
  • Highlights the importance of IFN-gamma in cellular immunity and cytokine networks.
  • Offers insights into potential therapeutic targets related to IFN-gamma signaling.

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