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Primary cutaneous marginal zone B-cell lymphoma: a report of 9 cases
A de la Fouchardière1, B Balme, B Chouvet
1Service d'Anatomie-Pathologique, Hôpital Edouard-Herriot, 69437 Lyon Cedex 3, France.
Insights
Marginal zone B-cell lymphoma (MZL) is the most common primary cutaneous lymphoma. This study details its distinct clinical, histologic, and outcome features in nine patients, noting long survival but potential for relapse.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous B-cell lymphoma encompasses diverse subtypes.
- Marginal zone B-cell lymphoma (MZL) is identified as the most prevalent subtype.
Purpose of the Study:
- To analyze the clinical presentation, histologic characteristics, and patient outcomes for primary cutaneous MZL.
- To characterize the distinct features of this lymphoma subtype.
Main Methods:
- Review of all primary cutaneous lymphoma cases over a decade.
- Identification and analysis of nine primary MZL cases.
Main Results:
- Nine cases of primary cutaneous MZL were analyzed, predominantly affecting elderly women in the upper body.
- Histologic findings revealed dense, deep-seated infiltrates with specific cell morphology (CD5, CD10, CD23 negative).
- Patients exhibited long survival, though relapses occurred in skin, lymph nodes, orbit, salivary glands, and breast.
Conclusions:
- Marginal zone B-cell lymphoma is the predominant type of primary cutaneous lymphoma in this cohort.
- Primary cutaneous MZL presents with unique histologic and clinical features and a characteristic outcome profile.
Background:
Primary cutaneous B-cell lymphoma is a heterogeneous group among which marginal zone B-cell lymphoma (MZL) appears to be the most common subtype.
Objective:
We analyze clinical presentation, histologic aspects, and outcome of patients with primary cutaneous MZL.
Methods:
All samples classified as primary cutaneous lymphoma over the past 10 years were reviewed, and cases of primary MZL were identified.
Results:
Nine cases of MZL were analyzed, all from the upper body region, with a predominance in elderly women. Histologic aspects included a dense, nodular, deep-seated infiltrate containing various proportions of small cells displaying a centrocyte-like, plasmacytoid or monocytoid appearance. Surface expression of CD5, CD10, and CD23 was negative. Long survival was noted but relapses in the skin, nodes, orbit, salivary glands, and breast were observed.
Conclusion:
MZL is the predominant primary cutaneous lymphoma of our study. It has distinctive histologic and clinical features as well as outcome.