Related Experiment Video

Updated: Aug 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

[Interferons (40 years since their discovery)]

F I Ershov

    Voprosy Virusologii
    |September 17, 1999
    PubMed

    Insights

    This review covers 40 years of interferon research, from initial discovery to modern clinical applications. It highlights the significant contributions of Russian scientists in understanding these vital immune proteins.

    Area of Science:

    • Immunology
    • Virology
    • Biochemistry

    Context:

    • Interferons (IFNs) are crucial cytokines in the innate immune response against viral infections and cancer.
    • Their discovery marked a significant advancement in understanding cellular defense mechanisms.
    • Research has evolved from basic observation to complex molecular and clinical investigations.

    Purpose:

    • To provide a comprehensive historical overview of interferon (IFN) research over four decades.
    • To detail the scientific journey from initial discovery to current biological understanding and clinical utility.
    • To emphasize the specific contributions of Russian scientists to the field of interferonology.

    Summary:

    • The review chronicles the 40-year history of interferon (IFN) discovery and research.
    • It traces the progression from experimental observation to scientific interpretation and biological cognition.
    • The modern clinical applications of IFNs and their inducers are discussed, alongside the role of Russian researchers.

    Impact:

    • This work consolidates the historical and scientific narrative of interferon research.
    • It underscores the therapeutic potential and evolving clinical applications of interferons.
    • It recognizes and highlights the foundational and ongoing contributions of Russian scientists in this field.

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