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Chemotactic activities of avian lymphocytes

K M Lam1

  • 1Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA.

Developmental and Comparative Immunology
|December 1, 1999
PubMed

Insights

Avian lymphocytes, including chicken T and B cells, demonstrate chemotaxis, migrating towards chemical signals. This indicates their ability to respond to chemoattractants for targeted immune responses.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Avian lymphocytes play a crucial role in immune responses.
  • Understanding lymphocyte migration is key to deciphering immune surveillance and response mechanisms.

Purpose of the Study:

  • To investigate the chemotactic capabilities of avian lymphocytes.
  • To determine if chicken and turkey lymphocytes respond to specific chemoattractants.

Main Methods:

  • Utilized a Boyden-type chamber assay to study chemotaxis.
  • Employed chicken lymphocytes, enriched T and B lymphocytes, and the RP-9 turkey B-lymphoblastoid cell line.
  • Tested various chemoattractants including lipopolysaccharide, fMLP, interleukin-8, MIP1-beta, and anti-chicken IgG/IgM antibodies.

Main Results:

  • Avian lymphocytes exhibited spontaneous migration into membranes without chemoattractants.
  • The presence of chemoattractants significantly increased the number of migrating lymphocytes.
  • Specific chemoattractants demonstrated varying degrees of chemoattraction for the tested avian cell types.

Conclusions:

  • Avian lymphocytes possess inherent migratory abilities.
  • These lymphocytes are responsive to chemical signals, exhibiting chemotaxis.
  • This migratory response facilitates lymphocyte accumulation at sites of chemical signal origin, crucial for immune functions.

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