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[Adhesion molecule ICAM-1 in patients with chronic polyarthritis--effects of inpatient rehabilitation]
W Kullich1, H Neff, G Pöllmann
1Ludwig Boltzmann Institut für Rehabilitation interner Erkrankungen, Saalfelden. lbirehab@salzburg.co.at
Insights
In rheumatoid arthritis, elevated intercellular adhesion molecule-1 (ICAM-1) levels correlate with disease activity and improve with rehabilitation. Rehabilitation also improved related clinical markers.
Area of Science:
- Immunology
- Rheumatology
Context:
- Rheumatoid arthritis (RA) involves leukocyte adhesion and migration, mediated by intercellular adhesion molecule-1 (ICAM-1).
- Elevated ICAM-1 levels are observed during the acute phase of RA.
- ICAM-1's role in immune response modulation is suggested by its correlation with neopterin.
Purpose:
- To investigate the role of ICAM-1 in rheumatoid arthritis.
- To assess the correlation between ICAM-1 levels and acute phase reactants.
- To evaluate the impact of multidisciplinary rehabilitation on ICAM-1 levels and clinical parameters in RA patients.
Summary:
- Significantly increased serum ICAM-1 levels were found in the acute phase of RA, correlating with neopterin levels.
- No correlation was observed between ICAM-1 and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), or serum amyloid A (SAA).
- A multidisciplinary rehabilitation program led to improvements in serum ICAM-1 levels and various clinical and laboratory parameters, including ESR, CRP, and pain.
Impact:
- ICAM-1 may serve as a biomarker for RA activity.
- Multidisciplinary rehabilitation effectively improves both ICAM-1 levels and overall clinical status in RA patients.
- Findings suggest ICAM-1 modulation is associated with successful RA management strategies.
Abstract:
In rheumatoid arthritis (RA) the adhesion molecule ICAM-1 mediates the adhesion of leucocytes following subsequent transendothelial migration including interactions and adhesion of several cell types such as fibroblasts, T-lymphocytes and synoviocytes. Significantly increased ICAM-1 levels were measured in the acute phase of RA. The correlation of ICAM-1 levels with the pteridine neopterin (p < or = 0.01) may reflect the role of this adhesion molecule in modulation of immune responses. Despite the significantly higher levels of acute phase reactions parallel to the elevated ICAM-1 levels, no correlations were found between ICAM-1 and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum-Amyloid A (SAA). During an in-patient multidisciplinary rehabilitation programme the levels of ICAM-1 in serum and the majority of all investigated laboratory and clinical parameters such as ESR, CRP, SAA, fibrinogen, pain, swollen and painful joint count, morning stiffness and health assessment questionnaire improved.