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Circulating intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in patients with

S Kado1, N Nagata

  • 1Department of Internal Medicine 5, Tokyo Medical University, Inashiki, Ibaraki, Japan. s-kado@tokyo-med.ac.jp

Diabetes Research and Clinical Practice
|March 21, 2000
PubMed

Insights

Elevated levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were observed in type 2 diabetes patients, suggesting their role in atherosclerosis development.

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Immunology

Background:

  • Type 2 diabetes mellitus is associated with an increased risk of atherosclerosis.
  • Adhesion molecules play a role in inflammatory processes and vascular disease.
  • Understanding the role of specific adhesion molecules in diabetic complications is crucial.

Purpose of the Study:

  • To investigate serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in patients with type 2 diabetes.
  • To determine the association between these adhesion molecules and diabetic macroangiopathy.
  • To explore the relationship between glycemic control (hemoglobin A1c) and adhesion molecule levels in diabetes.

Main Methods:

  • Serum samples were collected from 64 patients with type 2 diabetes and 40 control subjects.
  • Concentrations of ICAM-1, VCAM-1, and E-selectin were measured using immunoassays.
  • Statistical analyses, including multiple regression, were performed to assess associations.

Main Results:

  • Serum ICAM-1 concentrations were significantly higher in diabetic patients compared to controls.
  • Hemoglobin A1c was independently associated with serum ICAM-1 levels in diabetic patients.
  • Serum VCAM-1 concentrations were elevated in diabetic patients with macroangiopathy compared to those without and controls.
  • No significant difference in E-selectin levels was found among the groups.

Conclusions:

  • Adhesion molecules, particularly ICAM-1 and VCAM-1, are elevated in type 2 diabetes.
  • These adhesion molecules may contribute to the development of atherosclerosis in diabetic patients.
  • VCAM-1 levels are associated with the presence of macroangiopathy in diabetes.

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