Related Experiment Video

Updated: Aug 10, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 4, 2010

Intracranial malignant B-cell lymphoma of the dura

D Freudenstein1, A Bornemann, U Ernemann

  • 1Department of Neurosurgery, University Hospital, Tübingen, Germany.

Clinical Neuropathology
|April 25, 2000
PubMed

Insights

Primary dural lymphoma, a rare condition, can mimic meningioma. This case highlights effective combined treatment with surgery and chemoradiotherapy for this uncommon brain tumor.

Area of Science:

  • Neuro-oncology
  • Hematology
  • Pathology

Background:

  • Malignant B-cell lymphomas of the dura mater are exceptionally rare.
  • Primary dural lymphomas present a diagnostic challenge, often mimicking other intracranial tumors.

Observation:

  • A 50-year-old woman presented with headache and seizures, exhibiting parafalcine and bilateral convexity lesions on imaging.
  • The dural lesion was subtotally resected, followed by adjuvant chemo- and radiotherapy.

Findings:

  • Histopathological analysis confirmed a primary centroblastic/centrocytic lymphoma of the dura.
  • Post-treatment evaluation revealed no evidence of systemic lymphoma or immunodeficiency.

Implications:

  • Combined surgical resection and chemoradiotherapy appears to be an effective therapeutic strategy for primary dural lymphoma.
  • This case underscores the importance of considering rare dural lymphomas in the differential diagnosis of convexity masses.
Abstract

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease06:25

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Published on: March 29, 2024

Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...