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An interleukin-6-producing cardiac myxoma associated with mediastinal lymphadenopathy

T Takizawa1, H Sumino, T Kanda

  • 1Cardiovascular Hospital of Central Japan, Hokkitsu-mura.

Cardiology
|June 9, 2000
PubMed

Insights

A cardiac myxoma secreting interleukin-6 (IL-6) caused mediastinal lymphadenopathy in a patient. Surgical removal of the myxoma resolved the lymphadenopathy and normalized IL-6 levels.

Area of Science:

  • Cardiology
  • Oncology
  • Immunology

Background:

  • Cardiac myxomas are rare primary heart tumors.
  • Mediastinal lymphadenopathy can have various causes, including malignancy and inflammation.

Observation:

  • A 68-year-old female presented with congestive heart failure and nocturnal chest discomfort.
  • Echocardiogram revealed a left atrial mass; CT scan showed enlarged mediastinal lymph nodes.
  • Serum interleukin-6 (IL-6) levels were significantly elevated.

Findings:

  • Surgical resection of the cardiac myxoma was performed.
  • Post-operatively, serum IL-6 levels normalized.
  • Repeat CT scans confirmed the resolution of mediastinal lymphadenopathy.

Implications:

  • Cardiac myxoma can induce systemic effects, including lymphadenopathy, via cytokine secretion.
  • Interleukin-6 (IL-6) overproduction by cardiac myxoma is a potential cause of mediastinal lymphadenopathy.
  • This case highlights the importance of considering cardiac tumors in the differential diagnosis of unexplained mediastinal lymphadenopathy.

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