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A cutaneous eruption from G-CSF in a healthy donor

A Torrelo1, L Madero, I G Mediero

  • 1Departments of Pediatric Dermatology, Hospital del Niño Jesús, Madrid, Spain.

Pediatric Dermatology
|July 8, 2000
PubMed

Insights

Granulocyte-colony stimulating factor (G-CSF) can cause a skin rash in healthy donors. This reaction involves atypical lymphocyte changes, suggesting G-CSF activates lymphocytes, leading to cellular alterations.

Area of Science:

  • Hematology
  • Dermatology
  • Immunology

Background:

  • Granulocyte-colony stimulating factor (G-CSF) is used to mobilize peripheral blood stem cells.
  • Stem cell collection procedures require careful monitoring for adverse effects.

Observation:

  • A healthy 12-month-old donor developed a papular, erythematous skin eruption after G-CSF treatment.
  • Histological examination revealed lymphocytes with irregular shapes and mitotic activity.

Findings:

  • The observed skin reaction is characterized by atypical lymphocyte morphology.
  • These changes suggest G-CSF may activate lymphocytes in healthy individuals.

Implications:

  • G-CSF administration can induce cutaneous reactions in healthy donors.
  • Understanding these reactions is crucial for managing stem cell donors.
  • Further research into G-CSF-mediated lymphocyte activation is warranted.

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