Related Experiment Video

Updated: Aug 9, 2026

Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry
08:30

Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Published on: October 9, 2018

Lymphocyte subsets and cellular immunity in patients with chronic pancreatitis

J Ockenga1, R Jacobs, A Kemper

  • 1Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany. Ocken@aol.com

Digestion
|July 19, 2000
PubMed

Insights

Chronic pancreatitis involves immune system changes, with decreased CD8+, CD56+, and CD25+ cells. Immune dysregulation may contribute to pain and tissue damage in this condition.

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Abnormal immune responses are implicated in chronic pancreatitis pathogenesis.
  • Systemic immunological changes in chronic pancreatitis patients require detailed characterization.

Purpose of the Study:

  • To investigate systemic immunological alterations in patients with chronic pancreatitis.
  • To correlate immune cell phenotypes and functions with disease characteristics like pain.

Main Methods:

  • Studied lymphocyte phenotypes and proliferation in peripheral mononuclear cells (PMNs) from 11 chronic pancreatitis patients.
  • Assessed natural killer (NK) cell activity and in vitro cytokine release from stimulated PMNs.

Main Results:

  • Found decreased circulating CD8+, CD56+, and CD25+ cells in chronic pancreatitis patients.
  • Observed increased in vitro release of tumor necrosis factor-alpha and interleukin-10.
  • Noted increased PMN proliferation in patients experiencing pain.

Conclusions:

  • Chronic pancreatitis is associated with systemic immune dysregulation.
  • Peripheral mononuclear cell changes suggest a role for cell-mediated immunity in pain and tissue destruction.
Abstract

More Related Videos

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity06:16

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 8, 2019

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...