Related Experiment Video

Updated: Aug 10, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 15, 2010

Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions

Y Aoki1, R Yarchoan, J Braun

  • 1Medicine Branch and HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. aokiy@mail.nih.gov

Blood
|August 15, 2000
PubMed

Insights

Kaposi sarcoma-associated herpesvirus encodes viral IL-6 (vIL-6), which is found in primary effusion lymphoma (PEL) effusions. This suggests vIL-6 plays a role in PEL development and symptoms.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Kaposi sarcoma-associated herpesvirus (KSHV) encodes viral IL-6 (vIL-6).
  • Primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma often associated with human immunodeficiency virus (HIV).
  • Cytokines like IL-6 and IL-10 are implicated in lymphomagenesis.

Purpose of the Study:

  • To investigate the role of vIL-6 in the pathogenesis of HIV-related PEL.
  • To quantify vIL-6 levels in PEL effusions.

Main Methods:

  • Development of a sensitive enzyme-linked immunosorbent assay (ELISA) for vIL-6 detection.
  • Analysis of vIL-6, human IL-6, and human IL-10 levels in PEL effusions and control effusions.

Main Results:

  • vIL-6 was detected in 6 of 8 PEL effusions, with concentrations ranging from 1390-66,630 pg/mL.
  • vIL-6 was not detected in any control effusions.
  • All PEL effusions contained human IL-6 and 7 of 8 contained detectable human IL-10.

Conclusions:

  • The presence of vIL-6 in PEL effusions suggests its involvement in PEL pathogenesis.
  • vIL-6, along with human IL-6 and IL-10, may contribute to PEL development and manifestations through mechanisms like increased vascular permeability.

More Related Videos

Peptide-based Identification of Functional Motifs and their Binding Partners14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: July 1, 2013

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals06:46

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...