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Spinal tuberculosis in HIV positive and negative patients: immunological response and clinical outcome
S Govender1, K Annamalai, K P Kumar
1Department of Orthopaedic Surgery, Faculty of Medicine, University of Natal, Congella, Durban, South Africa. thompson@med.und.ac.za
Insights
Cytokine secretion patterns did not differ between human immunodeficiency virus (HIV)-positive and HIV-negative patients with spinal tuberculosis. Postoperative outcomes and neurological recovery were similar in both groups, regardless of HIV status.
Area of Science:
- Immunology
- Infectious Diseases
- Neurosurgery
Background:
- Spinal tuberculosis presents a significant global health challenge.
- The impact of human immunodeficiency virus (HIV) infection on the immune response to spinal tuberculosis requires further elucidation.
- Understanding cytokine profiles is crucial for assessing disease pathogenesis and patient outcomes.
Purpose of the Study:
- To compare cytokine secretion patterns in peripheral blood and granulation tissue between HIV-positive and HIV-negative patients with spinal tuberculosis.
- To evaluate postoperative morbidity and neurological recovery in these patient groups.
- To investigate the influence of HIV status on the inflammatory response in spinal tuberculosis.
Main Methods:
- Flow cytometry was utilized to measure cytokine secretion.
- Samples were collected from peripheral blood and granulation tissue.
- 16 HIV-positive and 26 HIV-negative patients with spinal tuberculosis were included.
Main Results:
- No significant differences in cytokine secretion patterns were observed between HIV-positive and HIV-negative patients.
- Postoperative morbidity showed no significant variation between the two groups.
- Neurological recovery outcomes were comparable between HIV-positive and HIV-negative individuals.
Conclusions:
- HIV status does not appear to significantly alter cytokine secretion patterns in spinal tuberculosis.
- Clinical outcomes, including postoperative morbidity and neurological recovery, are similar in HIV-positive and HIV-negative patients with spinal tuberculosis when not on anti-retroviral therapy.
Abstract:
We measured cytokine secretion patterns in peripheral blood and granulation tissue by flow cytometry in 16 human immunodeficiency virus (HIV) positive and 26 HIV negative patients with spinal tuberculosis. Anti-retroviral therapy was not prescribed. There were no significant differences in the postoperative morbidity and neurological recovery between the two groups.