Related Experiment Video
Updated: Aug 12, 2026
On-Chip Endothelial Inflammatory Phenotyping
Published on: July 22, 2012
[Interest in variations in soluble ICAM-1 plasma levels. From physiology to clinical applications]
E Gomez-Scotto1, M Seigneur, M Renard
1Laboratoire Universitaire d'Hématologie, Université Victor Ségalen, Bordeaux, France.
Insights
Intracellular adhesion molecule 1 (ICAM-1) is an immunoglobulin superfamily member on endothelial cells. Activated ICAM-1 mediates stable leukocyte adhesion by binding integrin receptors, influencing cell interactions.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Context:
- Intracellular adhesion molecule 1 (ICAM-1) is an immunoglobulin superfamily member expressed on endothelial cells.
- ICAM-1 plays a crucial role in leukocyte adhesion to the endothelium.
- Both membrane-bound and soluble forms of ICAM-1 exist.
Purpose:
- To describe the role of ICAM-1 in cell adhesion.
- To elucidate the binding interactions of ICAM-1 with leukocyte integrins.
Summary:
- ICAM-1, an adhesion molecule, is present on endothelial cell membranes.
- Upon activation, ICAM-1 facilitates stable leukocyte adhesion to the endothelial surface.
- ICAM-1 binds leukocyte integrin receptors like LFA-1 and Mac-1, modulating cell adhesion processes.
Impact:
- Understanding ICAM-1 function is vital for studying inflammatory and immune responses.
- This knowledge can inform therapeutic strategies targeting leukocyte-endothelial interactions.
- ICAM-1's role in cell adhesion impacts various physiological and pathological conditions.
Abstract:
Intracellular adhesion molecule 1 (ICAM-1) is an adhesion-related molecule belonging to the immunoglobulin superfamily. This molecule is found on the cell membrane of endothelial cells. When activated ICAM-1 allows stable leukocyte adhesion to the endothelial surface. ICAM-1 is found not only in the membrane form but also circulating in serum. ICAM-1 (extracellular part of ICAM-1). This enables ICAM-1s to bind leukocyte integrin receptors such as LFA-1 (CDI1a/CD18) and Mac-1 (CDI1b/CD18) and therefore provide adaptive changes in the adhesion process between circulating cells and the endothelium.
