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Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
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Candida albicans cerebral granulomas associated with a nonfunctional cerebrospinal fluid shunt: case report

J L Soto-Hernández1, M A Ramírez-Crescencio, V M Moreno Estrada

  • 1Department of Infectious Diseases, National Institute of Neurology and Neurosurgery, Mexico City, Mexico. Sotohe51@prodigy.net.mx

Neurosurgery
|October 3, 2000
PubMed

Insights

A rare case of Candida albicans granulomas in the basal ganglia is presented. Prompt antifungal treatment and shunt removal led to complete recovery in an immunocompetent patient.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Cerebrospinal fluid (CSF) shunts are used to treat hydrocephalus.
  • Infections associated with CSF shunts can lead to serious complications.

Observation:

  • A previously healthy 22-year-old woman presented with headache and hemiplegia.
  • Imaging revealed inflammatory masses in the basal ganglia surrounding a nonfunctional CSF shunt.

Findings:

  • Brain biopsy confirmed granulomas caused by Candida albicans.
  • Cultures of tissue and shunt hardware yielded C. albicans.
  • The patient received intravenous amphotericin B and oral ketoconazole.

Implications:

  • Candida albicans brain granulomas are rare in immunocompetent individuals.
  • Complete resolution is possible with timely antifungal therapy and shunt removal.
  • This case highlights the importance of considering fungal infections in shunt-related complications.
Abstract

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