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[Activated C protein resistance manifested by cutaneous necrosis after interferon alpha injection: case report]

F Plurien1, Z Le Lostec, C Pauwels

  • 1Service de médecine interne A, centre hospitalier Poissy-Saint-Germain, Saint-Germain-en-Laye, France.

La Revue De Medecine Interne
|October 20, 2000
PubMed

Insights

Alpha interferon treatment can rarely cause skin necrosis. This case links interferon-induced skin necrosis to a patient with resistance to activated protein C, suggesting coagulation issues may be involved.

Area of Science:

  • Dermatology
  • Hematology
  • Pharmacology

Background:

  • Cutaneous necrosis is an uncommon side effect of alpha interferon therapy.
  • The exact mechanism behind interferon-induced skin necrosis is not fully understood.
  • A local thrombotic action of interferon has been hypothesized.

Observation:

  • A 64-year-old male with HIV-related Kaposi's sarcoma developed skin necrosis.
  • The patient had been treated with interferon alpha for nine months.
  • The patient exhibited known resistance to activated protein C.

Findings:

  • This is the first reported case associating interferon-induced cutaneous necrosis with activated protein C resistance.
  • The patient's presentation suggests a potential link between coagulation abnormalities and this adverse drug reaction.

Implications:

  • Investigating coagulation disorders is recommended for patients experiencing interferon treatment-induced cutaneous necrosis.
  • This case raises questions about a potential pro-coagulant profile that may predispose individuals to this side effect.
  • Further research is needed to elucidate the role of coagulation in interferon-induced skin necrosis.
Abstract

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