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CD72, a negative regulator of B-cell responsiveness

J R Parnes1, C Pan

  • 1Department of Medicine, Stanford University School of Medicine, California, USA. jrparnes@leland.stanford.edu

Immunological Reviews
|October 24, 2000
PubMed

Insights

CD72 regulates B-cell development and responsiveness. CD72-deficient mice revealed its crucial role as a nonredundant negative regulator in B-cell activation and development.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Lymphocyte responsiveness is modulated by regulatory proteins.
  • CD72, a C-type lectin superfamily member, is expressed on B lymphocytes.
  • Previous studies suggested both positive and negative regulatory roles for CD72.

Purpose of the Study:

  • To investigate the physiological role of CD72 in B-lymphocyte development and activation.
  • To clarify the regulatory function of CD72 in the immune system.

Main Methods:

  • Generation of CD72-deficient mice.
  • Analysis of B-cell development and activation in these mice.
  • Utilizing anti-CD72 antibodies in prior studies.

Main Results:

  • CD72 is essential for normal B-cell development.
  • CD72 functions as a negative regulator of B-cell responsiveness.
  • SHP-1 recruitment by CD72 suggests an inhibitory mechanism.

Conclusions:

  • CD72 is a nonredundant regulator of B-cell development.
  • CD72 negatively regulates B-cell activation thresholds.
  • Elucidating CD72's role provides insights into immune regulation.

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