Related Experiment Video

Updated: Aug 11, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Follicular stromal cells and lymphocyte homing to follicles

J G Cyster1, K M Ansel, K Reif

  • 1Department of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA. cyster@itsa.ucsf.edu

Immunological Reviews
|October 24, 2000
PubMed

Insights

Follicular dendritic cells (FDCs) present antigens to B lymphocytes. B-lymphocyte chemoattractant (BLC) guides B cells to FDCs, aiding immune responses within lymphoid follicles.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Follicular dendritic cells (FDCs) are key stromal cells in lymphoid follicles, crucial for antigen presentation to B lymphocytes.
  • Understanding the cellular interactions within lymphoid follicles is vital for comprehending adaptive immunity.

Purpose of the Study:

  • To review the role of B-lymphocyte chemoattractant (BLC) in guiding B cells to FDCs.
  • To discuss the properties of BLC-expressing follicular stromal cells and FDCs.
  • To propose a model for FDC development incorporating BLC expression and lymphocyte trafficking.

Main Methods:

  • Review of existing research on BLC, follicular stromal cells, and FDCs.
  • Analysis of chemokine expression patterns and their impact on lymphocyte migration.
  • Development of a conceptual model for FDC development and function.

Main Results:

  • Follicular stromal cells expressing BLC attract CXCR5+ cells, facilitating contact between motile B cells and stationary FDCs.
  • BLC plays a significant role in the spatial organization of immune cells within lymphoid follicles.
  • Antigen recognition alters T and B lymphocyte chemokine responsiveness, influencing their movement into or out of follicles.

Conclusions:

  • BLC is a critical chemokine mediating B cell localization to FDCs, essential for effective antigen presentation.
  • A proposed model integrates BLC expression into FDC development and function.
  • Lymphocyte trafficking within lymphoid follicles is dynamically regulated by chemokine responsiveness changes upon antigen recognition.

More Related Videos

Isolation of Murine Lymph Node Stromal Cells05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry07:39

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...