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Cutaneous immunocytoma presenting with multiple infiltrated macules and papules
1Department of Dermatology, University of Graz, Austria. elisabeth.aberer@kfunigraz.ac.at
Insights
Cutaneous immunocytomas, a type of skin lymphoma, can present as unusual skin lesions. This case details a lymphoplasmocytic lymphoma manifesting as multiple brown-red macules and papules on a patient
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Cutaneous immunocytomas are defined as low-grade malignant B-cell lymphomas originating in the skin.
- They typically present as solitary or multiple papules, plaques, or nodules.
Observation:
- A female patient presented with multiple, brown-red to bluish macules and papules on her left thigh.
- The lesions were indicative of a lymphoplasmocytic lymphoma.
Findings:
- Immunohistochemical analysis confirmed the plasma cells were positive for IgG heavy chain and lambda-light chain.
- Polymerase chain reaction demonstrated immunoglobulin heavy-chain gene rearrangement, confirming monoclonal proliferation.
- The patient showed no evidence of paraproteinemia or bone marrow involvement.
Implications:
- This case highlights a specific presentation of cutaneous lymphoplasmocytic lymphoma.
- Understanding such presentations is crucial for accurate dermatological and hematological diagnosis.
- Further research into cutaneous B-cell lymphomas can improve patient outcomes.
Abstract:
Cutaneous immunocytomas are low-grade malignant B-cell lymphomas that arise in the skin as solitary or multiple papules, plaques, or nodules. We describe a female patient with lymphoplasmocytic lymphoma who presented with multiple, brown-red to bluish macules and papules on the left thigh. The proliferation was monoclonal as evaluated by positive staining of the plasma cells with antibodies against IgG heavy chain and lambda-light chain and with polymerase chain reaction showing immunoglobulin heavy-chain gene rearrangement. Neither paraproteinemia nor involvement of bone marrow was present.