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Pulmonary mucosa-associated lymphoid tissue lymphoma in a patient with common variable immunodeficiency syndrome

F Reichenberger1, C Wyser, M Gonon

  • 1Division of Pneumology, Department of Internal Medicine, University Hospital, Basel, Switzerland.

Respiration; International Review of Thoracic Diseases
|February 27, 2001
PubMed

Insights

Common variable immunodeficiency (CVID) patients with progressive lung disease may develop mucosa-associated lymphoid tissue (MALT) lymphoma. This rare B-cell lymphoma should be considered in CVID patients with worsening pulmonary symptoms.

Area of Science:

  • Immunology
  • Oncology
  • Pulmonology

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by recurrent sinopulmonary infections.
  • Malignancies, particularly non-Hodgkin's lymphoma, are recognized late complications of CVID.

Observation:

  • A CVID patient presented with recurrent sinopulmonary infections, interstitial lung changes, and hepatic granulomas.
  • Despite immunoglobulin therapy, the patient's pulmonary reticular and nodular changes progressed.
  • Video-assisted thoracoscopic lung biopsy revealed a low-grade B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the bronchus.

Findings:

  • The lung biopsy confirmed MALT lymphoma without evidence of infection.
  • This finding suggests a potential link between CVID and the development of pulmonary MALT lymphoma.

Implications:

  • Pulmonary MALT lymphoma should be included in the differential diagnosis for progressive lung disease in CVID patients.
  • Early recognition and diagnosis of MALT lymphoma in CVID can guide appropriate treatment and management strategies.

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