Related Experiment Video

Updated: Aug 11, 2026

Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells

M A Borrello1, J Palis, R P Phipps

  • 1Vaccinex, L.P., Laboratory of Cellular Immunology, Rochester, NY, USA.

International Reviews of Immunology
|May 9, 2001
PubMed

Insights

Normal biphenotypic CD5(+) B/macrophage cells exist in mice, challenging previous assumptions about malignancy. These cells may represent an ancient cell type with dual roles in innate and adaptive immunity.

Area of Science:

  • Immunology
  • Cell Biology
  • Evolutionary Biology

Background:

  • Historically, macrophage-like cells derived from CD5(+) pre-B cell lymphomas were reported.
  • Recent findings indicate that biphenotypic CD5(+) B/macrophage cells are not solely a product of malignancy.

Purpose of the Study:

  • To review the existence and function of normal biphenotypic CD5(+) B/macrophage cells.
  • To explore the evolutionary context of these dual-function cells in immunity.

Main Methods:

  • Literature review of studies on CD5(+) B cell lymphomas and normal biphenotypic cells.
  • Analysis of evolutionary perspectives on primitive cell functions.

Main Results:

  • Normal biphenotypic cells exhibiting both CD5(+) B lymphocyte and macrophage characteristics have been identified in mice.
  • These findings suggest that biphenotypic cells are not exclusively associated with cancerous conditions.

Conclusions:

  • The existence of normal CD5(+) B/macrophage cells provides new insights into immune cell plasticity.
  • These cells may represent an evolutionarily conserved cell type capable of bridging innate and adaptive immune responses.

More Related Videos

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line06:38

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...