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Host immune responses in the course of bovine leukemia virus infection

H Kabeya1, K Ohashi, M Onuma

  • 1Department of Veterinary Medicine, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa, Japan.

The Journal of Veterinary Medical Science
|August 16, 2001
PubMed

Insights

Bovine leukemia virus (BLV) infection is linked to host immune responses. Major histocompatibility complex (MHC) haplotype may influence resistance, suggesting breeding strategies for BLV control.

Area of Science:

  • Veterinary Immunology
  • Oncoviruses
  • Animal Genetics

Background:

  • Bovine leukemia virus (BLV) causes enzootic bovine leukosis, a disease with a long incubation period.
  • The pathogenesis of BLV infection is closely associated with host immune responses.
  • Understanding these interactions is crucial for developing effective control strategies.

Purpose of the Study:

  • To review and summarize existing data on the relationship between BLV and host immune responses.
  • To explore the role of cell-mediated immunity, cytokine profiles, and TNFalpha in BLV infection.
  • To investigate the influence of major histocompatibility complex (MHC) haplotype on BLV resistance.

Main Methods:

  • Review of accumulated data on BLV and host immune responses.
  • Analysis of studies on cell-mediated immunity and cytokine profiles in BLV-infected cattle.
  • Focus on tumor necrosis factor alpha (TNFalpha) and its receptors in leukemogenesis.
  • Examination of the regulation of TNFalpha expression by MHC haplotype.

Main Results:

  • Cell-mediated immunity plays a role in host protection against BLV.
  • Changes in cytokine profiles correlate with BLV disease progression.
  • Tumor necrosis factor alpha (TNFalpha) may be involved in BLV-induced leukemogenesis.
  • TNFalpha expression is regulated by MHC haplotype, suggesting innate resistance factors.

Conclusions:

  • Host immune responses, particularly those influenced by MHC haplotype, are critical in managing BLV infection.
  • A breeding strategy utilizing MHC haplotype could be an effective approach for BLV control.
  • Further research integrating immunological and genetic factors is warranted for comprehensive BLV management.

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