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Significance of interferon-gamma in coronary artery bypass surgery

S J Alrawi1, A A Abo Deeb, M Samee

  • 1Department of Surgery, Research Institute of MMC & LMC, Maimonides Medical Center, Brooklyn, New York 11219, USA.

JSLS : Journal of the Society of Laparoendoscopic Surgeons
|September 11, 2001
PubMed

Insights

Endoscopic vein harvesting for coronary artery bypass surgery (CABG) shows no significant difference in gamma interferon (IFN-gamma) levels compared to the open method. This suggests endoscopic harvesting is a viable alternative with potential benefits.

Area of Science:

  • Immunology
  • Cardiovascular Surgery

Background:

  • Gamma interferon (IFN-gamma) is a cytokine produced by immune cells during pathological conditions.
  • Elevated IFN-gamma levels are associated with inflammatory responses.

Purpose of the Study:

  • To compare the levels of IFN-gamma in patients undergoing coronary artery bypass surgery (CABG) using either open or endoscopic vein harvesting techniques.
  • To investigate the potential impact of surgical approach on immune response markers.

Main Methods:

  • Analysis of IFN-gamma levels in pre- and post-operative sera from 90 CABG patients.
  • Measurement of IFN-gamma in supernatants from 3-day endothelial cell cultures obtained via open and endoscopic saphenous vein harvesting.

Main Results:

  • No significant difference was found in pre-operative (0.09 pg/mL) versus post-operative (0.08 pg/mL) serum IFN-gamma levels.
  • Endothelial cell cultures from endoscopic (0.18 pg/mL) and open (0.19 pg/mL) vein harvesting methods showed comparable IFN-gamma levels.
  • Statistical analysis revealed no significant differences in IFN-gamma levels between the two surgical approaches (P=0.2 and P=0.89).

Conclusions:

  • The endoscopic vein harvesting method is recommended for CABG due to its associated lower morbidity and shorter hospital stays.
  • Surgical approach for vein harvesting does not appear to significantly influence perioperative IFN-gamma levels.
Abstract

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